The University of Malawi was established in 1965, founded a few months after Malawi achieved Independence.
The first enrolment consisted of 90 students in Blantyre. Teaching began in 1965 in Blantyre, and within two years the Institute of Public Administration at Mpemba, the Soche Hill College of Education and the Polytechnic in Blantyre, and Bunda College in Lilongwe became colleges of the university.
In 1973, all the constituents of the university apart from the polytechnic and Bunda College moved to Zomba and were merged into Chancellor College. In 1979, Kamuzu College of Nursing became a college of the university.