Missouri is a state in the Midwestern region of the United States. Humans have inhabited the land now known as Missouri for at least 12,000 years. The Mississippian culture built cities and mounds, before declining in the 14th century. When European explorers arrived in the 17th century, they encountered the Osage and Missouria nations.
The French established Louisiana, a part of New France, founding Ste. Genevieve in 1735 and St. Louis in 1764. After a brief period of Spanish rule, the United States acquired the Louisiana Purchase in 1803. Americans from the Upland South, including enslaved African Americans, rushed into the new Missouri Territory. Missouri was admitted as a slave state as part of the Missouri Compromise. Many from Virginia, Kentucky and Tennessee settled in the Boonslick area of Mid-Missouri. Soon after, heavy German immigration formed the Missouri Rhineland.
Missouri played a central role in the westward expansion of the United States, as memorialized by the Gateway Arch. The Pony Express, Oregon Trail, Santa Fe Trail and California Trail all began in Missouri. As a border state, Missouri’s role in the American Civil War was complex and there were many conflicts within. After the war, both Greater St. Louis and the Kansas City metropolitan area became centers of industrialization and business.
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